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Effects American psychologist and counterculture figure Timothy Leary conducted early experiments into the effects of psychedelic drugs, including psilocybin (1989 photo) Buy Jolly Mushroom Gummies

The effects of psilocybin are highly variable and depend on the mindset and environment in which the user has the experience, factors commonly referred to as set and setting.

In the early 1960s, Timothy Leary and colleagues at Harvard University investigated the role of set and setting on the effects of psilocybin.

They administered the drug to 175 volunteers from various backgrounds in an environment intended to be similar to a comfortable living room.

98 of the subjects were given questionnaires to assess their experiences and the contribution of background and situational factors.Buy Jolly Mushroom Gummies

Individuals who had experience with psilocybin prior to the study reported more pleasant experiences than those for whom the drug was novel. Group size, dosage, preparation, and expectancy were important determinants of the drug response.

In general, those in groups of more than eight felt that the groups were less supportive, and their experiences less pleasant. Conversely, smaller groups (fewer than six) were seen as more supportive and reported more positive reactions to the drug in those groups.

Leary and colleagues proposed that psilocybin heightens suggestibility, making an individual more receptive to interpersonal interactions and environmental stimuli.[5]

These findings were affirmed in a later review by Jos ten Berge (1999), who concluded that dosage, set, and setting were fundamental factors in determining the outcome of experiments that tested the effects of psychedelic drugs on artists’ creativity.[6]

After ingesting psilocybin, a wide range of subjective effects may be experienced: feelings of disorientation, lethargy, giddiness, euphoria, joy, and depression.

In one study, 31% of volunteers given a high dose reported feelings of significant fear and 17% experienced transient paranoia.

[7] In studies at Johns Hopkins among those given a moderate dose (but still enough to “give a high probability of a profound and beneficial experience”),

negative experiences were rare, whereas one-third of those given a high dose experienced anxiety or paranoia.[8][9] Low doses can induce hallucinatory effects.

Some individuals report synesthesia, such as tactile sensations when viewing colors.[11]: 175  At higher doses, psilocybin can lead to “intensification of affective responses

Open-eye visual hallucinations are common, and may be very detailed although rarely confused with reality.[10] A 2011 prospective study by Roland R. Griffiths and colleagues suggests that a single high dosage of psilocybin can cause long-term changes in the personality of its users.

About half of the study participants—described as healthy, “spiritually active”, and many possessing postgraduate degrees—showed an increase in the personality dimension of openness (assessed using the Revised NEO Personality Inventory), and this positive effect was apparent more than a year after the psilocybin session.

According to the study authors, the finding is significant because “no study has prospectively demonstrated personality change in healthy adults after an experimentally manipulated discrete event”.[13]

A further study by Griffiths in 2017 found that doses of 20 to 30mg/70kg psilocybin inducing mystical-type experiences brought more lasting changes to traits including altruism, gratitude,

forgiveness and feeling close to others when they were combined with a regular meditation practice and an extensive spiritual practice support program.

Although other researchers have described instances of psychedelic drug usage leading to new psychological understandings and personal insights,[16] it is not known whether these experimental results can be generalized to larger populations.[13]